Isonitriles as herbicide extenders

ABSTRACT

Herbicidally active thiolcarbamates are employed in combination with certain substituted phenyl isonitriles having the formula ##STR1## in which R 1  is selected from the group consisting of C 1  -C 6  alkyl, C 1  -C 6  alkoxy, C 1  -C 6  alkylthio, phenyl, halogen, benzylthio, and p-chlorobenzylthio, and 
     R 2  is selected from the group consisting of hydrogen, C 1  -C 6  alkyl, C 1  -C 6  alkoxy, and halogen. 
     In a typical application, the isonitrile is included in sufficient quantity to lessen the rate of soil degradation of the thiolcarbamate. As a result, the herbicidal effectiveness of the thiolcarbamate is enhanced and prolonged, rendering a single application of the herbicide effective over a longer period of time.

This is a division, of application Ser. No. 196,226, filed Oct. 14, 1980.

BACKGROUND OF THE INVENTION

This invention relates to herbicide extenders, herbicidal compositions, and herbicidal methods. In particular, this invention is addressed to the problem of herbicidal degradation occurring in certain soils.

Thiolcarbamates are well known in the agricultural art as herbicides useful for weed control in crops such as corn, potatoes, beans, beets, spinach, tobacco, tomatoes, alfalfa, and rice. Thiolcarbamates are primarily used in pre-emergence application, and are particularly effective when incorporated into the soil prior to the planting of the crop. The concentration of the thiolcarbamate in the soil is greatest immediately after application of the compound. How long thereafter the initial concentration is retained depends in large part on the particular soil used. The rate at which the thiolcarbamate concentration declines following its application varies from one type of soil to the next. This is evident both in the observable extent of weed control and in the detectable presence of undegraded thiolcarbamate remaining in the soil after considerable time has elapsed.

It is therefore an object of this invention to increase the soil persistence of thiolcarbamate herbicides and thus improve their herbicidal effectiveness.

BRIEF DESCRIPTION OF THE INVENTION

It has now been discovered that the soil persistence of certain herbicidally active thiolcarbamates is significantly extended by the further addition to the soil of certain extender compounds in the form of substituted phenyl isonitriles, which have little or no herbicidal activity of their own and do not increase the herbicidal activity of the thiolcarbamate. This improvement in the soil persistence of thiolcarbamates manifests itself in a variety of ways. It can be shown, for example, by soil analyses taken at regular intervals, that the rate of decrease of the thiolcarbamate content of the soil is substantially lessened. Improved soil persistence can also be shown by improvements in herbicidal efficacy, as evidenced by a higher degree of weed injury brought about when the extender compound increases the soil persistence of the thiolcarbamate, prolonging its effective life.

In particular, this invention relates to a novel herbicidal composition comprising

(a) an herbicidally effective amount of a thiolcarbamate having the formula ##STR2## in which R¹, R², and R³ are independently C₂ -C₄ alkyl; and

(b) an amount of a substituted phenyl isonitrile sufficient to extend the soil life of said thiolcarbamate, said isonitrile having the formula ##STR3## in which R⁴ is selected from the group consisting of C₁ -C₆ alkyl, C₁ -C₆ alkoxy, C₁ -C₆ alkylthio, phenyl, halogen, benzylthio, and p-chlorobenzylthio, and

R⁵ is selected from the group consisting of hydrogen, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, and halogen.

Within the scope of the present invention, certain embodiments are preferred, namely:

In the thiolcarbamate formula, R¹ is preferably ethyl, and R² and R³ are each preferably propyl.

In the isonitrile formula, R⁴ is preferably selected from the group consisting of C₁ -C₄ alkyl, methoxy, methylthio, phenyl, chlorine, benzylthio, and p-chlorobenzylthio; and R⁵ is preferably selected from the group consisting of hydrogen, C₁ -C₂ alkyl, methoxy, and chlorine.

This invention further relates to a method of controlling undesirable vegetation comprising applying the above compositions to the locus where control is desired.

In addition, several of the above isonitriles are novel, namely those having the formula ##STR4## in which R⁴ is C₁ -C₆ alkyl and R⁵ is chlorine or C₁ -C₆ alkyl. Within the scope of this formula, R⁴ is preferably C₁ -C₄ alkyl, and R⁵ is preferably chlorine or C₁ -C₄ alkyl. Most preferably, R² is chlorine or C₁ -C₂ alkyl.

The terms "alkyl," "alkoxy," and "alkylthio" are used herein to include both straight-chain and branched-chain groups. All carbon atom ranges are inclusive of their upper and lower limits.

The term "herbicide," as used herein, means a compound or composition which controls or modifies the growth of plants. By the term "herbicidally effective amount" is meant any amount of such compound or composition which causes a modifying effect upon the growth of plants. By "plants" is meant germinant seeds, emerging seedlings, and established vegetation, including roots and above-ground portions. Such controlling or modifying effects include all deviations from natural development, such as killing, retardation, defoliation, desiccation, regulation, stunting, tillering, stimulation, leaf burn, dwarfing and the like.

The phrase "to extend the soil life of said thiolcarbamate" as used herein means to retard the rate at which molecules of thiolcarbamate are broken down into decomposition products when in contact with soil and/or to prolong the period of time following application in which herbicidal effects can be observed. This applies both to field sites where repeated applications of thiolcarbamates result in decreasing herbicidal effectiveness, and to field sites where a decline in herbicidal activity is detected over time regardless of the prior history of herbicidal applications. An extended soil life can be demonstrated by a slower rate of decline of weed-killing activity, or an increased half-life of thiolcarbamate concentration in the soil. Other techniques of determining soil life are readily apparent to one skilled in the art.

DETAILED DESCRIPTION OF THE INVENTION

Thiolcarbamates within the scope of the present invention can be prepared by the process described in U.S. Pat. No. 2,913,327 (Tilles et al., Nov. 17, 1959). Examples of such thiolcarbamates include S-ethyl di-n-propylthiolcarbamate, S-ethyl diisobutylthiolcarbamate, S-n-propyl di-n-propylthiolcarbamate, and S-n-propyl ethyl-n-butylthiolcarbamate.

Isonitriles within the scope of this invention can be prepared by the processes described in Gokel et al., "Phase-Transfer Hofmann Carbylamine Reaction: tert-Butyl Isocyanide," Organic Synthesis, Vol. 55, pp. 95-99 (1975); Weber et al., "Phase Transfer Catalysis in the Hofmann Carbylamine Reaction," Angew. Chem. Internat. Edit., Vol. 11, No. 6, pp. 530-531 (1972); and Weber et al. "An Improved Procedure for the Hofmann Carbylamine Synthesis of Isonitriles," Tetrahedron Letters, No. 17, pp. 1637-1640 (1972). In general, there are three methods of preparation: (1) the alkylation of silver cyanide with alkyl iodides to yield silver isonitrile complexes from which the isonitrile is obtained by treatment with potassium cyanide; (2) the treatment of primary amines with chloroform and strong base; and (3) the dehydration of monosubstituted formamides. Method (2) can be considerably improved by the use of a phase transfer catalyst, such as a quaternary ammonium or phosphonium salt.

The objects of the present invention are achieved by applying the isonitrile extender compound to the soil at an agricultural field site in conjunction with the thiolcarbamate herbicide. The two compounds can be applied simultaneously in a single mixture or in separate formulations, or they can be applied in succession, with either one following the other. In successive application, it is preferable to add the compounds as close in time as possible.

The herbicide extending effect is operable over a wide range of ratios of the two compounds. It is most convenient, however, to apply the compounds at a ratio of about 1:1 to about 20:1 (herbicide:extender) on a weight basis, preferably about 1:1 to about 5:1, and most preferably about 1:1 to about 2:1.

The variety of crops on which the present composition is useful can be significantly broadened by the use of an antidote to protect the crop from injury and render the composition more selective against weeds.

For antidote descriptions and methods of use, reference is made to U.S. Pat. Nos. 3,959,304, issued to E. G. Teach on May 25, 1976; 3,989,503, issued to F. M. Pallos et al. on Nov. 2, 1976; 4,021,224, issued to F. M. Pallos et al. on May 3, 1977; 3,131,509, issued to O. L. Hoffman on May 5, 1964; and 3,564,768 , issued to O. L. Hoffman on Feb. 3, 1971.

Examples of useful antidotes include acetamides such as N,N-diallyl-2,2-dichloroacetamide and N,N-diallyl-2-chloroacetamide, oxazolidines such as 2,2,5-trimethyl-N-dichloroacetyl oxazolidine and 2,2-spirocyclohexyl-N-dichloroacetyl oxazolidine, and 1,8-naphthalic anhydride. For maximum effect, the antidote is present in the composition in a non-phytotoxic, antidotally effective amount. By "non-phytotoxic" is meant an amount which causes at most minor injury to the crop. By "antidotally effective" is meant an amount which substantially decreases the extent of injury caused by the herbicide to the crop. The preferred weight ratio of herbicide to antidote is about 3:1 to about 20:1.

The first five examples which follow are offered to illustrate the preparation of the compounds of this invention. Their activity is demonstrated in Example 6.

EXAMPLE 1 2,6-Dimethylphenylisonitrile

A reaction flask was charged with 48.4 g (0.4 mole) of 2,6-dimethylaniline, 50 ml of chloroform, 50 ml of methylene chloride, and 1.0 g of methyl tricaprylylammonium chloride (designated by the trade name "Aliquat 336®" and obtained from General Mills Co., Chemical Division, Kankakee, Ill.). The flask was placed in a water bath at room temperature. As the flask contents were vigorously stirred, 150 ml of 50% aqueous sodium hydroxide was added. Stirring was continued overnight. The reaction mixture was then poured into 400 ml of ice water and extracted with 200 ml of diethyl ether. The ether phase was separated and washed with water, dried, and stripped. The residue was then extracted with 200 ml of hot hexane which was subsequently stirred with 20 g of Florisil® silica absorbent material and filtered. The filtrate was chilled in a dry ice/acetone bath and filtered to yield 35.2 g of a tan-colored solid. The structure indicated by the above title was confirmed by infrared spectra, nuclear magnetic resonance, and mass spectroscopy.

EXAMPLE 2 2-Benzylthio-5-chlorophenylisonitrile

A reaction flask was charged under a nitrogen atmosphere with 6 g (0.03 mole) of 2-mercapto-5-chloroaniline hydrochloride, 4 g (0.03 mole) of benzyl chloride, 5 ml of 50% aqueous sodium hydroxide, and 250 mg of tetra-n-butylphosphonium chloride. The mixture was heated to reflux for two hours, and 3 ml each of benzene and water were added. The organic phase was then washed with a 10% caustic solution and evaporated to yield 8.1 g of a black oil, confirmed by mass spectroscopy to be 2-benzylthio-5-chloroaniline.

A reaction flask was then charged with 6 g (0.02 mole) of this product, 5 ml of chloroform, 10 ml of methylene chloride, 10 ml of 50% aqueous sodium hydroxide solution, and 100 mg of benzyltriethylammonium chloride. The procedure of Example 1 was then followed, producing 6 g of a black oil, which was passed through an alumina chromatography column with hexane, followed by a hexane-benzene mixture. The result was 1.5 g of a red semisolid, whose structure was confirmed by mass spectroscopy as that of the title compound.

EXAMPLE 3 2-Phenyl phenylisonitrile

A reaction flask was charged with 17 g (0.1 mole) of 2-phenylaniline, 20 ml of methylene chloride, 15 ml of chloroform, 30 ml of 50% aqueous sodium hydroxide, and 200 mg of benzyltriethylammonium chloride. The procedure of Example 1 was followed, yielding 6 g of a thick oil, whose structure was confirmed by mass spectroscopy as that indicated by the above title.

EXAMPLE 4 2,6-Diethylphenylisonitrile

The procedure of Example 1 was again followed, using 75 g (0.5 mole) of 2,6-diethylaniline, 60 ml of chloroform, 100 ml of methylene chloride, 200 ml of 50% aqueous sodium hydroxide, and 700 mg of benzyltriethylammonium chloride. The product was an oil weighing 36 g, with structure confirmed by mass spectroscopy.

EXAMPLE 5 2-Methyl-6-chlorophenylisonitrile

The procedure of Example 1 was again followed, using 100 g (0.7 mole) of 2-methyl-6-chloroaniline, 75 ml of chloroform, 100 ml of methylene chloride, 175 ml of 50% aqueous sodium hydroxide, and 1 g of benzyltriethylammonium chloride. The product was a solid weighing 44 g, with structure confirmed by mass spectroscopy.

The physical properties of these and other compounds similarly prepared are shown in Table I.

                  TABLE I                                                          ______________________________________                                         PHYSICAL PROPERTIES                                                            Com-                                                                           pound                                                                          No.   Structural Formula                                                                               Property                                               ______________________________________                                                ##STR5##         boiling point 115° C. (0.1 mm pressure)         2                                                                                     ##STR6##         melting point 41-47° C.                         3                                                                                     ##STR7##         boiling point 78-82° C. (0.1 mm pressure)       4                                                                                     ##STR8##         thick oil                                              5                                                                                     ##STR9##         thick oil                                              6                                                                                     ##STR10##        melting point 46-52° C.                         7                                                                                     ##STR11##        thick oil                                              8                                                                                     ##STR12##        boiling point 50-55° C. (0.1 mm pressure)       9                                                                                     ##STR13##        refractive index n .sub.D.sup.30 = 1.5350              10                                                                                    ##STR14##        refractive index n .sub.D.sup.30 = 1.5280              11                                                                                    ##STR15##        refractive index n .sub.D.sup.30 = 1.5412              12                                                                                    ##STR16##        crude solid                                            13                                                                                    ##STR17##        refractive index n .sub.D.sup.30 = 1.5213              14                                                                                    ##STR18##        refractive index n .sub.D.sup.30 = 1.5410              15                                                                                    ##STR19##        boiling point 60-65° C. (0.1 mm                 ______________________________________                                                                 pressure)                                         

EXAMPLE 6

This example shows, by soil analysis, the effectiveness of the isonitriles of the present invention in extending the soil life of thiolcarbamates. The thiolcarbamate used in this test was S-ethyl di-n-propylthiolcarbamate, commonly known as EPTC. The soil was a sandy loam soil obtained from Sunol, Calif., containing approximately (on a weight basis) 64% sand, 29% silt, and 7% clay, determined by mechanical means. The total organic content of the soil was approximately 4% by weight and the pH was 6.8, both determined by chemical analysis.

The test procedure involved an initial pre-treatment of the soil to simulate field conditions where the soil had been previously treated with EPTC, followed by a soil persistence test, as described below.

A. Soil Pre-Treatment

An emulsion was prepared by diluting an emulsifiable liquid concentrate containing 6 lb/gal (0.72 kg/l) of the thiolcarbamate in 100 ml of water, such that the concentration of thiolcarbamate in the resulting emulsion was 4000 mg/l. Five ml of this emulsion was then added to 10 lb (4.54 kg) of soil and the mixture was mixed in a rotary mixer for 10-20 seconds.

Round plastic containers, 9 inches (22.9 cm) in diameter by 9 inches (22.9 cm) deep, were then filled with the sandy loam soil, which was tamped and leveled with a row marker to impress three rows across the width of each container. Two rows were seeded with DeKalb XL-45A corn Zea mays (L.), and one row was seeded with barnyardgrass Echinochloa crusgalli (L.). Sufficient seeds were planted to produce several seedlings per row. The containers were then placed in a greenhouse maintained at 20° C. to 30° C. and watered daily by sprinkler.

Five weeks after treatment, the soil was allowed to dry out and the plant foliage was removed. The soil was then passed through a 0.25 inch (0.64 cm) screen, followed by a 2-millimeter (mm) screen, to remove plant roots and clods.

B. Soil Persistence Test

A 100-gram quantity (air-dry basis) of the pre-treated soil was placed in an 8-ounce (0.25 liter) wide-mouth glass bottle. The same emulsifiable concentrate described in Part A above was appropriately diluted in water such that a 5-ml portion added to the soil would produce a herbicide concentration of 6 ppm (weight) in the soil. This is equivalent to an application rate of 6 pounds per acre (6.7 kilograms) per hectare) in a field where the herbicide is incorporated into the soil through a depth of about 2 inches (5.08 cm) soon after application. A selected extender compound in technical (nonformulated) form was then diluted in an acetone-water mixture such that a one-ml portion added to the soil would produce a concentration of 4 ppm by weight, equivalent to 4 pounds per acre (4.5 kilograms per hectare). On these bases, the herbicide and extender were added to the bottle containing the soil. The bottle was then sealed with a lid and shaken manually for approximately 15 minutes.

Following such treatment, the soil was moistened with 20 ml of deionized water. The bottle was then covered with a watch glass to maintain aerobic conditions and to prevent rapid soil drying, and placed in a controlled environmental chamber in darkness, where the temperature was maintained constant at 25° C.

Two days later, the bottle was removed from the environmental chamber and 50 ml of water and 100 ml of toluene were added. The bottle was then tightly sealed with a lid containing a cellophane liner, and vigorously shaken on a variable speed, reciprocating shaker (Eberbach Corp. Model 6000) set at approximately 200 excursions per minute for one hour. After shaking, the bottle contents were allowed to settle, and a 10 ml aliquot of toluene was transferred by pipette into a glass vial and sealed with a polyseal cap. The toluene extract was analyzed for herbicidal content by gas chromatography. The chromatogram data was then converted to equivalent soil concentrations in parts per million (ppm) by weight of the herbicide.

The results are shown in the table below, where the fifteen compounds shown in Table I were tested in three separately treated batches of soil. A control run without an extender compound was conducted for each soil batch, to show how the drop in herbicide concentration was affected by the extender compound. In each case, the quantity of herbicide remaining in the soil after two days was dramatically increased when the extender compound was added.

                  TABLE II                                                         ______________________________________                                         2-DAY SOIL PERSISTENCE DATA                                                    Herbicide: S--Ethyl di-n-propylthiolcarbamate (EPTC) at 6 lb/A                 (6 ppm in soil)                                                                Extender: As shown at 4 lb/A (4 ppm in soil)                                   ______________________________________                                                                    EPTC Residue                                        Extender                   After 2 Days (ppm)                                  Compound                   With     Without                                    No.      Structural Formula                                                                               Extender Extender                                   ______________________________________                                         Soil Batch A:                                                                   1                                                                                       ##STR20##        0.28     0.03                                        2                                                                                       ##STR21##        1.37     0.03                                        3                                                                                       ##STR22##        0.82     0.03                                        4                                                                                       ##STR23##        0.80     0.03                                        5                                                                                       ##STR24##        0.74     0.03                                        6                                                                                       ##STR25##        1.24     0.03                                        7                                                                                       ##STR26##        0.70     0.03                                        8                                                                                       ##STR27##        1.02     0.03                                       Soil Batch B:                                                                   9                                                                                       ##STR28##        0.63     0.04                                       ______________________________________                                                              EPTC Residue                                                                   After 4 Days (ppm)                                        Compound                   With     Without                                    No.      Structural Formula                                                                               Extender Extender                                   ______________________________________                                         Soil Batch B:                                                                  10                                                                                       ##STR29##        0.38     0.04                                       11                                                                                       ##STR30##        1.85     0.04                                       12                                                                                       ##STR31##        0.88     0.04                                       13                                                                                       ##STR32##        1.78     0.04                                       14                                                                                       ##STR33##        2.12     0.04                                       Soil Batch C:                                                                  15                                                                                       ##STR34##        1.89     0.40                                       ______________________________________                                    

METHODS OF APPLICATION

The herbicidal compositions, of the present invention are useful in controlling the growth of undesirable vegetation by pre-emergence or post-emergence application to the locus where control is desired, including pre-plant and post-plant soil incorporation as well as surface application. The compositions are generally embodied in formulations suitable for convenient application, containing additional ingredients or diluent carriers to aid in the dispersal of the compositions. Examples of such ingredients or carriers are water, organic solvents, dusts, granules, surface active agents, water-oil emulsions, wetting agents, dispersing agents, and emulsifying agents. The formulated compositions generally take the form of dusts, emulsifiable concentrates, granules, or microcapsules.

A. DUSTS

Dusts are dense powder compositions which combine the active compounds with a dense, free-flowing solid carrier. They are intended for application in dry form and are designed to settle rapidly to avoid being windborne to areas where their presence is not desired.

The carrier may be of mineral or vegetable origin, and is preferably an organic or inorganic powder of high bulk density, low surface area, and low liquid absorptivity. Suitable carriers include micaceous talcs, pyrophyllite, dense kaolin clays, tobacco dust, and ground calcium phosphate rock.

The performance of a dust is sometimes aided by the inclusion of a liquid or solid wetting agent, of ionic, anionic, or nonionic character. Preferred wetting agents include alkylbenzene and alkylnaphthalene sulfonates, sulfated fatty alcohols, amines or acid amides, long chain acid esters of sodium isothionate, esters of sodium sulfosuccinate, sulfated or sulfonated fatty acid esters, petroleum sulfonates, sulfonated vegetable oils, and ditertiary acetylenic glycols. Dispersants are also useful in the some dust compositions. Typical dispersants include methyl cellulose, polyvinyl alcohol, lignin sulfonates, polymeric alkylnaphthalene sulfonates, sodium naphthalene sulfonate, polymethylene bisnaphthalenesulfonate, and sodium-N-methyl-N-(long chain acid) taurates.

In addition, inert absorptive grinding aids are frequently included in dust compositions to aid in the manufacturing of the dust. Suitable grinding aids include attapulgite clay, diatomaceous silica, synthetic fine silica and synthetic calcium and magnesium silicates.

In typical dust compositions, carriers are usually present in concentrations of from about 30 to 90 weight percent of the total composition. The grinding aid usually constitutes about 5 to 50 weight percent, and the wetting agent up to about 1.0 weight percent. Dispersants, when present, constitute up to about 0.5 weight percent, and minor amounts of anticaking and antistatic agents may also be present. The particle size of the entire composition is usually about 30 to 50 microns.

B. EMULSIFIABLE CONCENTRATES

Emulsifiable concentrates are solutions in which the active materials and an emulsifying agent are dissolved in a nonwatermiscible solvent. Prior to use, the concentrate is diluted with water to form a suspended emulsion of solvent droplets.

Typical solvents for use in emulsifiable concentrates include weed oils, chlorinated hydrocarbons, and nonwater-miscible ethers, esters, and ketones.

Typical emulsifying agents are anionic or nonionic surfactants, or mixtures of the two. Examples include long-chain mercaptan polyethoxy alcohols, alkylaryl polyethoxy alcohols, sorbitan fatty acid esters, polyoxyethylene ethers with sorbitan fatty acid esters, polyoxyethylene glycol esters with fatty or rosin acids, fatty alkylol amide condensates, calcium and amine salts of fatty alcohol sulfates, oil soluble petroleum sulfonates, or preferably mixtures of these emulsifying agents. Such emulsifying agents usually comprise about 1 to 10 weight percent of the total composition.

Typical emulsifiable concentrates contain about 15 to 50 weight percent active material, about 40 to 82 weight percent solvent, and about 1 to 10 weight percent emulsifier. Other additives such as spreading agents and stickers can also be included.

C. GRANULES

Granules are physically stable, particulate compositions in which the active ingredients adhere to or are distributed throughout a basic matrix of a coherent, inert carrier with macroscopic dimensions. A typical particle is about 1 to 2 millimeters in diameter. Surfactants are often present to aid in the leaching of the active ingredient from the granule to the surrounding medium.

The carrier is preferably of mineral origin, and generally falls within one of two types. The first are porous, absorptive, preformed granules, such as attapulgite or heat expanded vermiculite. A solution of the active agent is sprayed on the granule at concentrations of up to 25 weight percent of the total weight. The second are powdered materials to which the active ingredients are added prior to being formed into granules. These materials include kaolin clays, hydrated attapulgite, or bentonite clays in the form of sodium, calcium, or magnesium bentonites. Water-soluble salts may also be present to help the granules disintegrate in water. These ingredients are blended with the active components, then granulated or pelleted, followed by drying. In the resulting composition, the active component is distributed uniformly throughout the mass. Granules can be made with as much as 25 to 30 weight percent active component, but more frequently a concentration of about 10 weight percent is desired for optimum distribution. Granule compositions are most useful in a size range of 15-30 mesh.

The surfactant is generally a common wetting agent of anionic or nonionic character. The most suitable wetting agents depend upon the type of granule used. When preformed granules are sprayed with active material in liquid form, the most suitable wetting agents are nonionic, liquid wetters miscible with the solvent. These are compounds generally known as emulsifiers, and comprise alkylaryl polyether alcohols, alkyl polyether alcohols, polyoxyethylene sorbitan fatty acid esters, polyethylene glycol esters with fatty or rosin acids, fatty alkylol amide condensates, oil solution petroleum or vegetable oil sulfonates, or mixtures of these. Such agents usually comprise up to about 5 weight percent of the total composition.

When the active ingredient is first mixed with a powdered carrier and subsequently granulated, liquid nonionic wetters can still be used, but it is usually preferable to incorporate at the mixing stage a solid, powdered anionic wetting agent comprising up to about 2.0 weight percent of the total composition.

Typical granules comprise about 5 to 30 percent by weight active material, about 0 to 5 weight percent wetting agent, and about 65 to 95 weight percent carrier.

D. MICROCAPSULES

Microcapsules are fully enclosed droplets or granules in which the active materials are enclosed in an inert porous membrane which allows the enclosed materials to escape to the surrounding medium at controlled rates.

Encapsulated droplets are typically about 1 to 50 microns in diameter. The enclosed liquid typically constitutes about 50 to 95% of the weight of the capsule, and may contain a small amount of solvent in addition to the active materials.

Encapsulated granules are characterized by porous membranes sealing the openings of the granule carrier pores, trapping the liquid containing the active components inside for controlled release. A typical granule size ranges from 1 millimeter to 1 centimeter in diameter. Granules formed by extrusion, agglomeration, or prilling are useful in the present invention as well as materials in their naturally occurring form. Examples of such carriers are vermiculite, sintered clay granules, kaolin, attapulgite clay, sawdust, and granular carbon.

Useful encapsulating materials include natural and synthetic rubbers, cellulosic materials, styrene-butadiene copolymers, polyacrylonitriles, polyacrylates, polyesters, polyamides, polyurethanes, and starch xanthates.

E. IN GENERAL

Each of the above formulations can be prepared as a package containing both the herbicide and the extender together with the other ingredients of the formulation (diluents, emulsifiers, surfactants, etc.), or as a tank mix in which the components are formulated separately and combined at the grower site. The two formulations in the tank mix can be of either the same type or two different types--e.g., the herbicide in microcapsule form and the extender as an emulsifiable concentrate. As a further alternative, the herbicide and extender can be applied sequentially. This is less preferred, however, since simultaneous application generally produces better results.

In general, any conventional method of application can be used. The locus of application can be soil, seeds, seedlings, or the actual plants, as well as flooded fields. Soil application is preferred. Dusts and liquid compositions can be applied by the use of powder dusters, boom and hand sprayers, and spray dusters. The compositions can also be applied from airplanes as dusts and sprays because they are effective in very low dosages. In order to modify or control the growth of germinating seeds or emerging seedlings, as a typical example, the dust and liquid compositions are applied to the soil according to conventional methods and are distributed to a depth of at least one-half inch below the soil surface. The compositions can either be mixed with the soil particles by discing, dragging, or mixing operations, or sprayed or sprinkled over the surface of the soil. The compositions can also be added to irrigation water so that they will accompany the water as it penetrates the soil.

The amount of active ingredient required for herbicidal effectiveness depends upon the nature of the seeds or plants to be controlled and the prevailing conditions. Usually, herbicidal effects are obtained with an application rate of about 0.01 to about 50 pounds per acre, preferably about 0.1 to about 25. It will be readily apparent to one skilled in the art that compositions exhibiting lower herbicidal activity will require a higher dosage than more active compounds for the same degree of control. 

What is claimed is:
 1. An herbicidal composition comprising(a) an herbicidally effective amount of a thiolcarbamate having the formula ##STR35## in which R¹, R², and R³ are independently C₂ -C₄ alkyl; and (b) an amount of a substituted phenyl isonitrile sufficient to extend the soil life of said thiolcarbamate, said isonitrile having the formula ##STR36## in which R⁴ is selected from the group consisting of C₁ -C₆ alkyl, C₁ -C₆ alkoxy, C₁ -C₆ alkylthio, phenyl, halogen, benzylthio, and p-chlorobenzylthio, and R⁵ is selected from the group consisting of hydrogen, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, and halogen.
 2. An herbicidal composition comprising an herbicidally effective amount of S-ethyl N,N-di-n-propylthiolcarbamate and an amount of a substituted phenyl isonitrile sufficient to extend the soil life of said thiolcarbamate, said isonitrile having the formula ##STR37## in which R⁴ is selected from the group consisting of C₁ -C₄ alkyl, methoxy, methylthio, phenyl, chlorine, benzylthio, and p-chorobenzylthio, andR⁵ is selected from the group consisting of hydrogen, C₁ -C₂ alkyl, methoxy, and chlorine.
 3. A composition according to claim 2 in which R⁴ is 2-ethyl and R⁵ is 6-ethyl.
 4. A composition according to claim 2 in which R⁴ is 2-sec-butyl and R⁵ is 6-ethyl.
 5. A composition according to claim 2 in which the weight ratio of thiolcarbamate to substituted phenyl isonitrile is from about 1:1 to about 2:1.
 6. An herbicidal composition comprising(a) an herbicidally effective amount of a thiolcarbamate having the formula ##STR38## in which R¹, R², and R³ are independently C₂ -C₄ alkyl; (b) an amount of a substituted phenyl isonitrile sufficient to extend the soil life of said thiolcarbamate, said isonitrile having the formula ##STR39## in which R⁴ is selected from the group consisting of C₁ -C₄ alkyl, methoxy, methylthio, phenyl, halogen, benzylthio, and p-chorobenzylthio, and R⁵ is selected from the group consisting of hydrogen, C₁ -C₂ alkyl, methoxy, and halogen; and (c) an inert diluent carrier.
 7. An herbicidal composition comprising an herbicidally effective amount of S-ethyl N,N-di-n-propylthiolcarbamate, an amount of a substituted phenyl isonitrile sufficient to extend the soil life of said thiolcarbamate, said isonitrile having the formula ##STR40## in which R⁴ is selected from the group consisting of C₁ -C₄ alkyl, methoxy, methylthio, phenyl, benzylthio, and and p-chorobenzylthio, andR⁵ is selected from the group consisting of hydrogen, C₁ -C₂ alkyl, methoxy, and chlorine,and an inert diluent carrier.
 8. A composition according to claim 7 in which R⁴ is 2-ethyl and R⁵ is 6-ethyl.
 9. A composition according to claim 7 in which R⁴ is 2-sec-butyl and R⁵ is 6-ethyl.
 10. A composition according to claim 7 in which the weight ratio of thiolcarbamate to substituted phenyl isonitrile is from about 1:1 to about 2:1.
 11. A method of controlling undesirable vegetation comprising applying to the locus where control is desired both(a) an herbicidally effective amount of a thiolcarbamate having the formula ##STR41## in which R¹, R², and R³ are independently C₂ -C₄ alkyl; and (b) an amount of a substituted phenyl isonitrile sufficient to extend the soil life of said thiolcarbamate, said isonitrile having the formula ##STR42## in which R⁴ is selected from the group consisting of C₁ -C₆ alkyl, C₁ -C₆ alkoxy, C₁ -C₆ alkylthio, phenyl, halogen, benzylthio, and p-chlorobenzylthio, and R⁵ is selected from the group consisting of hydrogen, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, and halogen.
 12. A method of controlling undesirable vegetation comprising applying to the locus where control is desired an herbicidal composition comprising an herbicidally effective amount of a substituted phenyl isonitrile sufficient to extend the soil life of said thiolcarbamate having the formula ##STR43## in which R⁴ is selected from the group consisting of C₁ -C₄ alkyl, methoxy, methylthio, phenyl, halogen, benzylthio, and p-chorobenzylthio, andR⁵ is selected from the group consisting of hydrogen, C₁ -C₂ alkyl, methoxy, and halogen.
 13. A composition according to claim 12 in which R⁴ is 2-ethyl and R⁵ is 6-ethyl.
 14. A composition according to claim 12 in which R⁴ is 2-sec-butyl and R⁵ is 6-ethyl.
 15. A composition according to claim 12 in which the weight ratio of thiolcarbamate to substituted phenyl isonitrile is from about 1:1 to 2:1.
 16. A method of extending the soil life of a thiolcarbamate having the formula ##STR44## in which R¹, R², and R³ are independently C₂ -C₄ alkyl; which comprises applying to the soil containing said thiolcarbamate or to which said thiolcarbamate is to be applied an effective amount of a substituted phenyl isonitrile having the formula ##STR45## in which R⁴ is selected from the group consisting of C₁ -C₆ alkyl, C₁ -C₆ alkylthio, phenyl, halogen, benzylthio, and p-chlorobenzylthio, andR⁵ is selected from the group consisting of hydrogen, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, and halogen.
 17. A method of extending the soil life of S-ethyl N,N-di-n-propylthiocarbamate which comprises applying to the soil containing said thiolcarbamate or to which said thiolcarbamate is to be applied an effective amount of a substitute phenyl isonitrile having the formula ##STR46## in which R⁴ is selected from the group consisting of C₁ -C₄ alkyl, methoxy, methylthio, phenyl, halogen, benzylthio, and p-chorobenzylthio, andR⁵ is selected from the group consisting of hydrogen, C₁ -C₂ alkyl, methoxy, and halogen.
 18. A method according to claim 17 in which R⁴ is 2-ethyl and R⁵ is 6-ethyl.
 19. A method according to claim 17 in which R⁴ is 2-sec-butyl and R⁵ is 6-ethyl.
 20. A method according to claim 17 in which the weight ratio of thiolcarbamate to substituted phenyl isonitrile is from about 1:1 to about 2:1. 